Guru (Marvin Miller) falls into a coma when he is attacked by an unknown assailant. He telepathically contacts Jonathan Kidd (Ted Knight) in the middle of the night to alert him and the rest of the CMDF team to his whereabouts.
From there, "The Mind of the Master" becomes the closest thing to an actual adaptation of the original novel upon which the 1966 movie was based. Oh, by the way, the common misconception with the movie was that Isaac Asimov's novelization of said film is mistakenly assumed to be the original source material.
Fantastic Voyage turns 50 in 2018. Anyone think a remake is in order for this series? Fox, are you paying attention?