Even Jonny Quest had to grow up sometime.
The Real Adventures of Jonny Quest, which anchored Cartoon Network's weekday Toonami block for 3 years (1996-9), was a troubled production behind the scenes. Cross-promoted and repurposed on sister networks TNT & TBS, which weren't afraid to run action cartoons back then, the series aired on a daily basis, the culmination of three years of preparation. However, the off-air issues led to a total overhaul of the series after the first 26 episodes aired.
Only one actor from the previous 2 series had returned, and that was Granville Van Dusen, who reprised his role as Roger "Race" Bannon for 2 episodes after the overhauling of the cast & crew. Prior to that, Robert Patrick ("Terminator 2: Judgment Day", among others) had been cast as Bannon, with game show host JD Roth (ex-Fun House) as Jonny, and George Segal as Dr. Benton Quest. By that point, Don Messick, the definitive Dr. Quest, was in failing health, and even though his predecessor as Dr. Quest, John Stephenson, was still available, he wasn't contacted. For the final 26 episodes, John DeLancie (ex-Star Trek: The Next Generation) replaced Segal, and Quinton Flynn took over as Jonny. Rob Paulsen, who'd voiced Hadji in 2 TV-movies for cable, reclaimed that role for "season 2".
For the sake of perhaps gender equality, Jessie, rebooted as Race's daughter by Jezebel Jade (she was a scientist's daughter in the 1980's series), was added to the team, creating plenty of friction with Jonny, who hadn't yet gotten out of the "girls are icky" phase. Personally, I thought that maybe, just maybe, there was a way for Jonny to finally break the ice, but before long the series was out of production, and any thoughts of Jessie hooking up with either Jonny or Hadji would be left to the imaginations of fans and fan-fiction sites.
Following is a "season 1" open & close.
It is this series that gave someone the impetus to mount plans for a live-action movie with Zac Efron ("High School Musical") as Jonny, but that never got past the talking stage, and likely would've bombed anyway.
Edit: 11/13/14: I realized after posting that this was the 2nd review of this series. Hey, we can't always be perfect.