A common thug named Rick Deacon became a villain known as The Fly, not to be confused, of course, with Archie Comics' heroic character of the same name, nor the stuntman known as The Human Fly, who'd land his own Marvel series a year after this Fly debuted.
However, the staff at DePatie-Freleng never consulted Marvel about their Fly when they were searching for villains to battle Spider-Woman. Instead, the writers opted for a generic mad scientist to turn into a hybrid half-man, half-fly, a la the movie, except that he has a working brain and can talk. He manages to rob our heroine (Joan Van Ark) of her powers long enough for viewers to see the TV version of her origin as she works to regain her powers.
Now, here's "Spider-Woman & The Fly":
Personally, I'd have preferred Deacon-Fly, who could've become a recurring foe if the series had been renewed. Instead, it marks its 35th anniversary this year as a footnote in cartoon history, that being the last series DFE sold to ABC.